@article {Plyusnin2008Automated,
	title = {Automated 3D Phenotype Analysis Using Data Mining},
	journal = {PLoS ONE},
	volume = {3},
	number = {3},
	year = {2008},
	month = {March},
	pages = {e1742+},
	publisher = {Public Library of Science},
	abstract = {The ability to analyze and classify three-dimensional (3D) biological morphology has lagged behind the analysis of other biological data types such as gene sequences. Here, we introduce the techniques of data mining to the study of 3D biological shapes to bring the analyses of phenomes closer to the efficiency of studying genomes. We compiled five training sets of highly variable morphologies of mammalian teeth from the MorphoBrowser database. Samples were labeled either by dietary class or by conventional dental types (e.g. carnassial, selenodont). We automatically extracted a multitude of topological attributes using Geographic Information Systems (GIS)-like procedures that were then used in several combinations of feature selection schemes and probabilistic classification models to build and optimize classifiers for predicting the labels of the training sets. In terms of classification accuracy, computational time and size of the feature sets used, non-repeated best-first search combined with 1-nearest neighbor classifier was the best approach. However, several other classification models combined with the same searching scheme proved practical. The current study represents a first step in the automatic analysis of 3D phenotypes, which will be increasingly valuable with the future increase in 3D morphology and phenomics databases.},
	keywords = {3d, gis, morphology, reconstruction},
	doi = {10.1371/journal.pone.0001742},
	url = {http://dx.doi.org/10.1371/journal.pone.0001742},
	author = {Plyusnin, Ilya and Evans, Alistair R. and Karme, Aleksis and Gionis, Aristides and Jernvall, Jukka}
}
